Structure of PDB 6xbb Chain E

Receptor sequence

>6xbbE (length=417) Species: 463191 (Streptomyces sviceus ATCC 29083) [Search protein sequence]

STVHDFVGIGLGPFNLGLACLTEPIDELDGIFLESKPDFEWHAGMFLDGA
HLQTPFMSDLVTLADPTSPYSFLNYLKEKGRLYSFYIRENFYPLRVEYDD
YCRWAANKLSSIRFGTTVTEVRYEDDLYVVTTSAGDVYRARHLVLGTGTP
PYIPEACQGLDGDFIHNSRYVQHRSELVKKESITIVGSGQSAAEIYQDLL
GEIDVHGYRLNWVTRSPRFFPLEYTKLTLEMTSPEYIDYYRELPEATRYR
LTAEQKGLFKGIDGDLINEIFDLLYQKNLAGPVPTRLLTNSSLNSARHEN
GTYTLAFRQEEQGKDFEIESQGLVLATGYKYAEPEFLAPVKDRLVYDSQG
NFDVSRAYAIDVTGRGVFLQNAGVHTHSITSPDLGMGAYRNSCIIRELLG
TEYYPVEKTIAFQEFSV

3D structure

PDB

6xbb Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus.

Chain

Resolution

2.366 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.59: L-lysine N(6)-monooxygenase (NADPH).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	E	G18 G20 P21 F22 E42 S43 K44 W49 H50 L60 T62 V126 T155 G156 Y337 N379 P390 D391 L392	G10 G12 P13 F14 E34 S35 K36 W41 H42 L52 T54 V118 T147 G148 Y329 N371 P382 D383 L384
BS02	NAP	E	H59 L60 Q61 R103 G195 S196 G197 Q198 S199 R223 S224 K264 F267 K268 L301 A334 T335	H51 L52 Q53 R95 G187 S188 G189 Q190 S191 R215 S216 K256 F259 K260 L293 A326 T327

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0047091	L-lysine 6-monooxygenase (NADPH) activity

	Biological Process
GO:0009058	biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6xbb, PDBe:6xbb, PDBj:6xbb
PDBsum	6xbb
PubMed	33784308
UniProt	B5HNG5

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