Structure of PDB 6x3c Chain E

Receptor sequence
>6x3cE (length=203) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
HGPDPENILPIKGNRNLQFIKPTITNENILVGEYSYYDSKRGESFEDQVL
YHYEVIGDKLIIGRFCSIGPGTTFIMNGANHRMDGSTYPFHLFRMGWEKY
MPSLKDLPLKGDIEIGNDVWIGRDVTIMPGVKIGDGAIIAAEAVVTKNVA
PYSIVGGNPLKFIRKRFSDGVIEEWLALQWWNLDMKIINENLPFIINGDI
EML
3D structure
PDB6x3c Synthetic group A streptogramin antibiotics that overcome Vat resistance.
ChainE
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SXA E G75 W126 G128 A146 A147 G69 W120 G122 A140 A141
BS02 O7S E Y59 G84 N86 H87 H97 L98 M107 P108 Y53 G78 N80 H81 H91 L92 M101 P102
BS03 MG E N164 P165 N158 P159
BS04 SXA E Y57 H87 M89 Y51 H81 M83
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6x3c, PDBe:6x3c, PDBj:6x3c
PDBsum6x3c
PubMed32968273
UniProtP26839|VATA_STAAU Virginiamycin A acetyltransferase (Gene Name=vat)

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