Structure of PDB 6wvv Chain E

Receptor sequence
>6wvvE (length=503) Species: 5855 (Plasmodium vivax) [Search protein sequence]
ATTVPQVVSLDPTTIPIDYHTPIDDLSIEVKDISAEACPADEGLIVFLLN
SQIKINDNTINEFLKNMENFTGKLGTSKSFYIANDQKKYVSLAYVGCGPA
NEETELEIRKVAYALVTLLHDSHKKVSIIFEIKIEEALFRFFLEHLFYEY
VTDERFKSADETDFIKNLSLHIANADAYKGQIDKARVYFYGTYYAAQLIA
APSNYCNPVSLSNAAVELAQKVNLECKILDVKELEELKMGAYLSVGKGSM
YPNKFIHLTYKGAQTKKKIALIGKGITFDSGGYNLKAAPGSMIDLMKFDM
SGCAAVLGCAYCIGTIKPDNVEVHFLSAVCENMVSKNSYRPGDIITASNG
KTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYA
GVFGNNDQLINKILSSSKTSNEPVWWLPIINEYRSSLNSKYADLNNISSS
VKASSVVASLFLKEFIENTPWAHIDIAGVSWNFKARKPKGFGVRLLTEFV
LND
3D structure
PDB6wvv Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases.
ChainE
Resolution2.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.13.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E K390 D395 D415 E477 K274 D279 D299 E361
BS02 ZN E D395 D475 E477 D279 D359 E361
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wvv, PDBe:6wvv, PDBj:6wvv
PDBsum6wvv
PubMed33303633
UniProtA5K3U9|AMPL_PLAVS Leucine aminopeptidase (Gene Name=LAP)

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