Structure of PDB 6wm3 Chain E

Receptor sequence
>6wm3E (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
YLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLE
VSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKP
IDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQK
IPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNM
ETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQ
CEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERA
GRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQI
YPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAV
VGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVFETLDIGWQLLRIFP
KEMLKRIPQSTLSEFYPR
3D structure
PDB6wm3 Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
ChainE
Resolution3.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H199 V236 N237 R400
Catalytic site (residue number reindexed from 1) H161 V198 N199 R362
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E R400 K403 R362 K365
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015078 proton transmembrane transporter activity
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0007035 vacuolar acidification
GO:0016241 regulation of macroautophagy
GO:0046034 ATP metabolic process
GO:0097401 synaptic vesicle lumen acidification
GO:1902600 proton transmembrane transport
Cellular Component
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0016324 apical plasma membrane
GO:0016469 proton-transporting two-sector ATPase complex
GO:0030665 clathrin-coated vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:0098850 extrinsic component of synaptic vesicle membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wm3, PDBe:6wm3, PDBj:6wm3
PDBsum6wm3
PubMed33065002
UniProtP21281|VATB2_HUMAN V-type proton ATPase subunit B, brain isoform (Gene Name=ATP6V1B2)

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