Structure of PDB 6w6j Chain E

Receptor sequence
>6w6jE (length=548) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
QALQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEP
GVGKTAIVEGLAQRIVAGDVPESLRDKTIVALDLGSMVRGEFEERLKAVL
DDIKNSAGQIITFIDELHTIVGNMIKPMLARGELRLVGATTLDEYRKHIE
KDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEVHHGVRITDSALVAAA
TLSDRYITARFLPDKAIDLVDEAASRLRMEIDKEEVGPDDIADVVSAWTG
IPAGRLLEGETAKLLRMEDELGKRVIGQKAAVTAVSDAVRRSRAGVSDPN
RPTGAFMFLGPTGVGKTELAKALADFLFDDERAMVRIDMSEYGEKHTVAR
LIGAPPGYVGYEAGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLD
EGRLTDGHGRTVDFRNTILILTSNLGSGGSAEQVLAAVRATFKPEFINRL
DDVLIFEGLNPEELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRG
FDPVYGARPLRRLVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSL
3D structure
PDB6w6j Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
ChainE
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E R252 G654 V656 R89 G357 V359
BS02 AGS E D178 V180 I181 G209 V210 G211 K212 T213 P388 D20 V22 I23 G51 V52 G53 K54 T55 P213
BS03 ADP E R571 V572 I573 G610 V611 G612 T614 R805 R274 V275 I276 G313 V314 G315 T317 R508
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0009408 response to heat
GO:0034605 cellular response to heat
GO:0042026 protein refolding
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w6j, PDBe:6w6j, PDBj:6w6j
PDBsum6w6j
PubMed34038719
UniProtP9WPD1|CLPB_MYCTU Chaperone protein ClpB (Gene Name=clpB)

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