Structure of PDB 6vvo Chain E

Receptor sequence
>6vvoE (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
WVDKYRPCSLGRLDYHKEQAAQLRNLVQCGDFPHLLVYGPSGAGKKTRIM
CILRELYGVGVEKLRIEHQTITTPSKKKIEISTIASNYHLEVNPSDAGNS
DRVVIQEMLKTVAQSQQLETNSQRDFKVVLLTEVDKLTKDAQHALRRTME
KYMSTCRLILCCNSTSKVIPPIRSRCLAVRVPAPSIEDICHVLSTVCKKE
GLNLPSQLAHRLAEKSCRNLRKALLMCEACRVQQYPFTADQEIPETDWEV
YLRETANAIVSQQTPQRLLEVRGRLYELLTHCIPPEIIMKGLLSELLHNC
DGQLKGEVAQMAAYYEHRLQLGSKAIYHLEAFVAKFMALYKKFMED
3D structure
PDB6vvo Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism
ChainE
Resolution3.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E V5 R9 P10 D17 Y18 G45 G47 K48 K49 T50 L223 R224 V2 R6 P7 D14 Y15 G42 G44 K45 K46 T47 L220 R221
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding
GO:0046683 response to organophosphorus
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0031390 Ctf18 RFC-like complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6vvo, PDBe:6vvo, PDBj:6vvo
PDBsum6vvo
PubMed
UniProtP40938|RFC3_HUMAN Replication factor C subunit 3 (Gene Name=RFC3)

[Back to BioLiP]