Structure of PDB 6vqa Chain E

Receptor sequence
>6vqaE (length=459) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLE
VSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKP
IDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQK
IPIFSAAGLPHNEIAAQICRQAGLVKKENFAIVFAAMGVNMETARFFKSD
FEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVIL
TDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGS
ITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPS
LSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSD
DLLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQ
STLSEFYPR
3D structure
PDB6vqa Structure of V-ATPase from the mammalian brain.
ChainE
Resolution3.7 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H199 V236 N237 R400
Catalytic site (residue number reindexed from 1) H161 V189 N190 R353
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E R400 K403 R353 K356
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0007035 vacuolar acidification
GO:0030641 regulation of cellular pH
GO:0046034 ATP metabolic process
GO:0097401 synaptic vesicle lumen acidification
GO:1902600 proton transmembrane transport
Cellular Component
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0016324 apical plasma membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0098850 extrinsic component of synaptic vesicle membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6vqa, PDBe:6vqa, PDBj:6vqa
PDBsum6vqa
PubMed32165585
UniProtP62815|VATB2_RAT V-type proton ATPase subunit B, brain isoform (Gene Name=Atp6v1b2)

[Back to BioLiP]