Structure of PDB 6vp0 Chain E

Receptor sequence
>6vp0E (length=404) Species: 9606 (Homo sapiens) [Search protein sequence]
WELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGI
LVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQA
GLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRD
VNSWCRRARAKHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRF
LLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLA
VPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNW
NIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFR
LWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYY
VLNY
3D structure
PDB6vp0 Structure and mechanism of human diacylglycerol O-acyltransferase 1.
ChainE
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.20: diacylglycerol O-acyltransferase.
2.3.1.76: retinol O-fatty-acyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P5S E M314 Y316 W429 T432 I463 M471 M237 Y239 W352 T355 I386 M394
BS02 3VV E W334 F338 W374 Q375 W377 H382 I386 Y390 K400 R404 S411 H415 W257 F261 W297 Q298 W300 H305 I309 Y313 K323 R327 S334 H338
BS03 AV0 E L103 Q298 W299 L40 Q221 W222
Gene Ontology
Molecular Function
GO:0003846 2-acylglycerol O-acyltransferase activity
GO:0004144 diacylglycerol O-acyltransferase activity
GO:0005515 protein binding
GO:0008374 O-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0042802 identical protein binding
GO:0050252 retinol O-fatty-acyltransferase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006640 monoacylglycerol biosynthetic process
GO:0006641 triglyceride metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0019915 lipid storage
GO:0034379 very-low-density lipoprotein particle assembly
GO:0035336 long-chain fatty-acyl-CoA metabolic process
GO:0042572 retinol metabolic process
GO:0046339 diacylglycerol metabolic process
GO:0046486 glycerolipid metabolic process
GO:0055089 fatty acid homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035579 specific granule membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6vp0, PDBe:6vp0, PDBj:6vp0
PDBsum6vp0
PubMed32433610
UniProtO75907|DGAT1_HUMAN Diacylglycerol O-acyltransferase 1 (Gene Name=DGAT1)

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