Structure of PDB 6vep Chain E

Receptor sequence
>6vepE (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPK
LIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKE
LGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNE
ECGDICPGNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCH
SECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFC
QDLHHKCCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
3D structure
PDB6vep A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
ChainE
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E D12 R14 N15 L37 F39 K40 R65 D9 R11 N12 L34 F36 K37 R62
BS02 peptide E R14 L36 L37 F64 F88 F89 F96 R118 R11 L33 L34 F61 F85 F86 F93 R115
External links
PDB RCSB:6vep, PDBe:6vep, PDBj:6vep
PDBsum6vep
PubMed32483339
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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