Structure of PDB 6v7w Chain E

Receptor sequence
>6v7wE (length=234) Species: 208963 (Pseudomonas aeruginosa UCBPP-PA14) [Search protein sequence]
DGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVG
NYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEE
ASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWML
KDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCS
EANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLIT
3D structure
PDB6v7w A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHN E L36 W60 Y64 D73 T75 V76 W88 L110 G126 S129 L32 W56 Y60 D69 T71 V72 W84 L106 G122 S125 BindingDB: EC50=139nM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001216 DNA-binding transcription activator activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0009372 quorum sensing
GO:0010468 regulation of gene expression
GO:0045893 positive regulation of DNA-templated transcription
GO:0051544 positive regulation of elastin biosynthetic process
GO:0060310 regulation of elastin catabolic process
Cellular Component
GO:0032993 protein-DNA complex

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Cellular Component
External links
PDB RCSB:6v7w, PDBe:6v7w, PDBj:6v7w
PDBsum6v7w
PubMed33412111
UniProtP25084|LASR_PSEAE Transcriptional activator protein LasR (Gene Name=lasR)

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