Structure of PDB 6uze Chain E

Receptor sequence
>6uzeE (length=562) Species: 1392 (Bacillus anthracis) [Search protein sequence]
TVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSP
EKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSK
NEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAG
FSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAP
IYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNA
QDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDT
GSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTL
KEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNATN
IYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSS
TEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGK
TFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKK
ILIFSKKGYEIG
3D structure
PDB6uze Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
ChainE
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E D177 D179 D181 I183 E188 D4 D6 D8 I10 E15
BS02 CA E D179 D181 E188 S222 K225 D235 D6 D8 E15 S49 K52 D62
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0043409 negative regulation of MAPK cascade
GO:0044533 positive regulation of apoptotic process in another organism
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0044164 host cell cytosol
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uze, PDBe:6uze, PDBj:6uze
PDBsum6uze
PubMed32047164
UniProtP13423|PAG_BACAN Protective antigen (Gene Name=pagA)

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