Structure of PDB 6usf Chain E

Receptor sequence
>6usfE (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQI
MTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGM
YEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSW
TYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITY
DFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLAL
TVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSP
TTHTMAPWVKVVFLEKLPALLFMQSVSEDWKYVAMVIDRLFLWIFVFVCV
FGTIGMF
3D structure
PDB6usf Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
ChainE
Resolution3.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QMR E V111 L121 V110 L120 BindingDB: Ki=0.480nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usf, PDBe:6usf, PDBj:6usf
PDBsum6usf
PubMed32221310
UniProtP17787|ACHB2_HUMAN Neuronal acetylcholine receptor subunit beta-2 (Gene Name=CHRNB2)

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