Structure of PDB 6u6c Chain E

Receptor sequence
>6u6cE (length=245) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVESGCDIIEV
GVPYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGRAVVMTY
WNPVLRYGVDAFARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRIF
LVAPSSTPERLAATVEASRGFVYAASQAAPELVGRVKAVSDIPVGVGLGV
RSRAQAAQIAQYADGVIVGSALVTALTEGLPRLRALTGELAAGVR
3D structure
PDB6u6c Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase.
ChainE
Resolution2.402 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E57 D68 Y181
Catalytic site (residue number reindexed from 1) E49 D60 Y173
Enzyme Commision number 4.2.1.20: tryptophan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALA E A262 G263 R265 A242 G243 R245
BS02 PZV E G66 M67 Y108 D136 G58 M59 Y100 D128
Gene Ontology
Molecular Function
GO:0004834 tryptophan synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:6u6c, PDBe:6u6c, PDBj:6u6c
PDBsum6u6c
PubMed31930594
UniProtP9WFY1|TRPA_MYCTU Tryptophan synthase alpha chain (Gene Name=trpA)

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