Structure of PDB 6t8x Chain E

Receptor sequence
>6t8xE (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKM
LQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGG
ELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLY
TSKRPNAILKLTDFGFAKETTCYTPYYVAPEVLGPEKYDKSCDMWSLGVI
MYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLI
RNLLKTEPTQRMTITEFMNHPWIMQST
3D structure
PDB6t8x Crystal structure of MAPKAPK2 (MK2) complexed with PF-3644022 and 5-(4-bromophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-2-furancarboxamide
ChainE
Resolution2.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 N191 D207 T226
Catalytic site (residue number reindexed from 1) D142 K144 N147 D163 T174
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B97 E L70 L72 V78 K89 K93 M138 C140 L141 D142 L193 T206 D207 L26 L28 V34 K45 K49 M94 C96 L97 D98 L149 T162 D163 BindingDB: IC50=201nM,Ki=5.0nM
BS02 MW8 E F147 I150 G259 Y260 P261 Y264 S265 N266 G268 F103 I106 G207 Y208 P209 Y212 S213 N214 G216
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6t8x, PDBe:6t8x, PDBj:6t8x
PDBsum6t8x
PubMed
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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