Structure of PDB 6sq8 Chain E

Receptor sequence
>6sq8E (length=494) Species: 531310 (Marinactinospora thermotolerans) [Search protein sequence]
MGYARRVMDGIGEVAVTGAGGSVTGARLRHQVRLLAHALTEAGIPPGRGV
ACLHANTWRAIALRLAVQAIGCHYVGLRPTAAVTEQARAIAAADSAALVF
EPSVEARAADLLERVSVPVVLSLGPTSRGRDIAASVPEGTPLRYREHPEG
IAVVAFTSGTTGTPKGVAHSSTAMSACVDAAVSMYGRGPWRFLIPIPLSD
LGGELAQCTLATGGTVVLLEEFQPDAVLEAIERERATHVFLAPNWLYQLA
EHPALPRSDLSSLRRVVYGGAPAVPSRVAAARERMGAVLMQNYGTQEAAF
IAALTPDDHARRELLTAVGRPLPHVEVEIRDDSGGTLPRGAVGEVWVRSP
MTMSGYWRDPERTAQVLSGGWLRTGDVGTFDEDGHLHLTDRLQDIIIVEA
YNVYSRRVEHVLTEHPDVRAAAVVGVPDPDSGEAVCAAVVVADGADPDPE
HLRALVRDHLGDLHVPRRVEFVRSIPVTPAGKPDKVKVRTWFTD
3D structure
PDB6sq8 Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System.
ChainE
Resolution2.59 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T158 D201 Q297 E298 I398 N403 K483
Catalytic site (residue number reindexed from 1) T157 D200 Q296 E297 I397 N402 K482
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQ2 E L202 G295 A300 F301 L201 G294 A299 F300
BS02 AMP E G271 A272 P273 Q292 Y294 T296 D377 N403 G270 A271 P272 Q291 Y293 T295 D376 N402
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:6sq8, PDBe:6sq8, PDBj:6sq8
PDBsum6sq8
PubMed32337091
UniProtR4R1U5

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