Structure of PDB 6s0s Chain E

Receptor sequence
>6s0sE (length=274) Species: 1967 (Streptomyces kanamyceticus) [Search protein sequence]
LAAPPGELTLALTPDDKTLDPASLDRALAILAEHGILVLTGMLRTRLTDQ
LRTAMLDDLPEVLRQQDVPTNFVPGHVQQDPPVRESLLFPDVLLNPVVYQ
ITHAVLGADARNAVYSGNMNLPGSHEQPVHLDEPHLWPGISHPPYCLCVD
VPLIDFTLENGSTEYWPGSHVLNPDECYDERGCVLPAELERRRAVAPPVR
FPIPVGSVVIRDGRLWHRGVPNLSAAPRPLLAMTHYTEWFDMPPIQLPDT
VKSWVDGSDRHTHAHFVAGDVDHL
3D structure
PDB6s0s A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates.
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.37: kanamycin B dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AKG E N73 N120 Q129 H132 T165 H219 G221 R230 N71 N118 Q127 H130 T163 H217 G219 R228
BS02 RIO E N73 F74 V116 N120 H132 D134 E135 A234 N71 F72 V114 N118 H130 D132 E133 A232
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:1901133 kanamycin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6s0s, PDBe:6s0s, PDBj:6s0s
PDBsum6s0s
PubMed32592631
UniProtQ6L732|KANJ_STRKN Kanamycin B dioxygenase (Gene Name=kanJ)

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