Structure of PDB 6rqc Chain E

Receptor sequence
>6rqcE (length=459) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MNVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKY
FNANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPL
QVEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYI
KLNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTI
LVMSRCGELMEDSCLRKRIIEEQITDCTDDQFQNVAANFIHLIVQAFHSY
TGNDIFALNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLS
QTYDLSIISKYLLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKK
EVNPRYLQPSLFAIERLLAIFQAIFPIQGKAESGSLSALREESLMKANIE
VFQNLSELHTLKLIATTMNKNIDYLSPKVRWKVNVPWEIIKEISESVHFN
ISDYFSDIH
3D structure
PDB6rqc Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM.
ChainE
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E Y363 K439 Y344 K420
BS02 dna E K367 K447 K348 K428
BS03 ATP E S39 G40 T41 G42 K43 T44 Y45 K49 I200 M203 I255 F256 S39 G40 T41 G42 K43 T44 Y45 K49 I200 M203 I255 F256
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex
GO:0035361 Cul8-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rqc, PDBe:6rqc, PDBj:6rqc
PDBsum6rqc
PubMed31748745
UniProtP50874|ORC5_YEAST Origin recognition complex subunit 5 (Gene Name=ORC5)

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