Structure of PDB 6q2o Chain E

Receptor sequence
>6q2oE (length=572) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
CQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFH
QFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREKYEL
VAVCTVHEEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVV
ATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQAN
GSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEP
3D structure
PDB6q2o Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
ChainE
Resolution3.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E E178 N179 D230 E232 D267 E142 N143 D191 E193 D224
BS02 CA E E232 D264 E265 D267 D302 E193 D221 E222 D224 D259
BS03 CA E D266 S268 D300 D302 Y314 D378 D223 S225 D257 D259 Y271 D335
BS04 CA E T564 C565 D567 H569 E574 D584 T514 C515 D517 H519 E524 D534
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q2o, PDBe:6q2o, PDBj:6q2o
PDBsum6q2o
PubMed31535977
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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