Structure of PDB 6q2n Chain E

Receptor sequence
>6q2nE (length=553) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
GECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGT
FHQFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREKY
ELVAVCTVHEEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDT
VVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQ
ANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSVLLLHFNVSVLP
VSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSCSTL
GVVTSAEDTSGILFVNPKCAELHYMVVATDQQTSRQAQAQLLVTVEGCPL
SCAVSKRRLECEECGGLGSPTGRCEWRQGKGITRNFSTCSPSTKTCPDGH
CDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCF
CEP
3D structure
PDB6q2n Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
ChainE
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E D266 S268 D300 D302 D378 D225 S227 D259 D261 D337
BS02 CA E E178 D264 E265 D267 E144 D223 E224 D226
BS03 CA E E178 D230 E232 D267 E144 D193 E195 D226
BS04 CA E T564 C565 D567 H569 E574 D584 T495 C496 D498 H500 E505 D515
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q2n, PDBe:6q2n, PDBj:6q2n
PDBsum6q2n
PubMed31535977
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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