Structure of PDB 6q2j Chain E

Receptor sequence

>6q2jE (length=571) Species: 9606 (Homo sapiens)

LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
PGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPG
TFHQFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREK
YELVAVCTVHEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDT
VVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQ
ANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSGVLLLHFNVSVL
PVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSCST
LGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLL
VTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGI
TRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRG
IKAGYGTCNCFPEEEKCFCEP

3D structure

• PDB: 6q2j Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
• Chain: E
• Resolution: 4.1 Å

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	E	D266 S268 D300 D302 D378	D225 S227 D259 D261 D337
BS02	CA	E	E232 D264 E265 D267 D302	E196 D223 E224 D226 D261
BS03	CA	E	E178 N179 D230 E232 D267	E145 N146 D194 E196 D226
BS04	CA	E	T564 C565 D567 H569 E574 D584	T513 C514 D516 H518 E523 D533

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6q2j, PDBe:6q2j, PDBj:6q2j
• PDBsum: 6q2j
• PubMed: 31535977
• UniProt: P07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)