Structure of PDB 6pv8 Chain E

Receptor sequence
>6pv8E (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
RVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNER
EQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNA
DGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKF
RSWTYDHTEIDMVLMTPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVD
VTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISVL
LALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHH
RSPSTHTMAPWVKRCFLHKLPTFLFMKRRQDVQEALEGVSFIAQHMKNDD
EDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLP
3D structure
PDB6pv8 Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
ChainE
Resolution3.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P1M E W59 I113 L121 L123 W59 I113 L121 L123
BS02 Y01 E L227 Y234 R439 L227 Y234 R368
BS03 Y01 E F287 C294 F316 F441 F287 C294 F316 F370
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0022900 electron transport chain
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:6pv8, PDBe:6pv8, PDBj:6pv8
PDBsum6pv8
PubMed31488329
UniProtP30926|ACHB4_HUMAN Neuronal acetylcholine receptor subunit beta-4 (Gene Name=CHRNB4)

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