Structure of PDB 6pmd Chain E

Receptor sequence
>6pmdE (length=182) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]
LIPTVIYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIY
LYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGK
RFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQS
IEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPE
3D structure
PDB6pmd Ureadepsipeptides as ClpP Activators.
ChainE
Resolution2.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G69 S98 M99 H123 D172
Catalytic site (residue number reindexed from 1) G58 S87 M88 H112 D161
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E L49 A53 T80 H83 L38 A42 T69 H72
BS02 peptide E D27 I29 Y61 Y63 I91 L115 D16 I18 Y50 Y52 I80 L104
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0051117 ATPase binding
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
Cellular Component
GO:0005737 cytoplasm
GO:0009368 endopeptidase Clp complex

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Cellular Component
External links
PDB RCSB:6pmd, PDBe:6pmd, PDBj:6pmd
PDBsum6pmd
PubMed31588734
UniProtQ2G036|CLPP_STAA8 ATP-dependent Clp protease proteolytic subunit (Gene Name=clpP)

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