Structure of PDB 6pek Chain E

Receptor sequence
>6pekE (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
NLANLIMNEIVDNGTAVKFDDIAGQDLAKQALQEIVILPSLRPELFTGLR
APARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL
VRALFAVARELQPSIIFIDEVDSLLCERREGEHDASRRLKTEFLIEFDGV
QSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLL
CKQGSPLTQKELAQLARMYSGSDLTALAKSPQTLEAYIRWNKD
3D structure
PDB6pek Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation.
ChainE
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E G385 N386 G387 K388 T389 M390 L517 G546 G63 N64 G65 K66 T67 M68 L195 G221
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6pek, PDBe:6pek, PDBj:6pek
PDBsum6pek
PubMed31767681
UniProtQ9UBP0|SPAST_HUMAN Spastin (Gene Name=SPAST)

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