Structure of PDB 6om8 Chain E

Receptor sequence

>6om8E (length=461) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]

KVSKVVCVGAGYVGGPTCAMIAHKCPHITVTVVDMNTAKIAEWNSDKLPI
YEPGLDEIVFAARGRNLFFSSDIPKAIAEADLIFISVNTPTKMRGKGMAP
DLKYVESVSRTIAQYAGGPKIVVEKSTVPVKAAESIGCILREAQKNNENL
KFQVLSNPEFLAEGTAMKDLANPDRVLIGGESSPEGLQAVAELVRIYENW
VPRNRIITTNTWSSELSKLVANAFLAQRISSINSISAVCEATGAEISEVA
HAVGYDTRIGSKFLQASVGFGGSCFQKDVLSLVYLCESLNLPQVADYWQG
VININNWQRRRFADKIIAELFNTVTDKKIAIFGFAFKKNTGDTRESSAIH
VIKHLMEEHAKLSVYDPKVQKSQMLNDLASVTSAQDVERLITVESDPYAA
ARGAHAIVVLTEWDEFVELNYSQIHNDMQHPAAIFDGRLILDQKALREIG
FRTFAIGTSPD

3D structure

PDB

6om8 Conservation of Atypical Allostery inC. elegansUDP-Glucose Dehydrogenase.

Chain

Resolution

2.449 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T136 E172 K227 N231 C283 D287
Catalytic site (residue number reindexed from 1)	T127 E163 K218 N222 C274 D278
Enzyme Commision number	1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UDX	E	G18 Y19 V20 D41 M42 K46 V94 N95 T96 Y113 S135 T136 R353	G11 Y12 V13 D34 M35 K39 V87 N88 T89 Y104 S126 T127 R344
BS02	UDX	E	F169 L170 A171 K227 I238 F272 Q274 S276 F279 G280 C283 F284 F345 K346 R447	F160 L161 A162 K218 I229 F263 Q265 S267 F270 G271 C274 F275 F336 K337 R438

Gene Ontology

	Molecular Function
GO:0003979	UDP-glucose 6-dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

	Biological Process
GO:0002009	morphogenesis of an epithelium
GO:0006024	glycosaminoglycan biosynthetic process
GO:0006065	UDP-glucuronate biosynthetic process
GO:0009792	embryo development ending in birth or egg hatching
GO:0018991	egg-laying behavior
GO:0022414	reproductive process
GO:0040025	vulval development

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6om8, PDBe:6om8, PDBj:6om8
PDBsum	6om8
PubMed	31616809
UniProt	Q19905\|UGDH_CAEEL UDP-glucose 6-dehydrogenase (Gene Name=sqv-4)

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