Structure of PDB 6o7e Chain E

Receptor sequence

>6o7eE (length=286) Species: 523850 (Thermococcus onnurineus NA1)

PKFIAVKLIPKGPFRDIPRADTLFGAIGNAISAIHGQSAVEELVDAFVGG
ARISSAFPYSGDTYYLPKPLSVEPALEGILTGLDEEERYTTAKRLRKAKY
LDLKNFELALRLRPFTIPEEIPYARVDVPRVVLDRVTQDSSIYFWEEIRF
REKSGVYFLYSGPREVFDGYIAPAMRFLGDTGIGGKSTWGAGLFEVEFHE
MKIDAPGSEYSVTLSNALPTKTPVLWRLLRKGGWSFGRRKPRMTFIAEGS
IVKNDPGGMERLELGLSHEVYVYGLTFPLGVELPEG

3D structure

• PDB: 6o7e Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
• Chain: E
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	T23 G26 A27 N30 S33 V132 V133 L134 R136 Q139 S141 I143 Y144 G183 I184 G185 G186 K187 T189 G233 G234 W235 S236 F237 K241 R243 H269 E270 Y272	T22 G25 A26 N29 S32 V131 V132 L133 R135 Q138 S140 I142 Y143 G182 I183 G184 G185 K186 T188 G232 G233 W234 S235 F236 K240 R242 H268 E269 Y271
BS02	rna	E	S141 S142	S140 S141
BS03	ANP	E	Y90 K94	Y89 K93

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:6o7e, PDBe:6o7e, PDBj:6o7e
• PDBsum: 6o7e
• PubMed: 31326272
• UniProt: B6YWC1|CSM4_THEON CRISPR system Cms protein Csm4 (Gene Name=csm4)