Structure of PDB 6nzu Chain E

Receptor sequence
>6nzuE (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
LRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMER
ARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTE
HKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTV
NNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSIS
GHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLG
AACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCIN
LSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSS
IRFGIGRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWT
QH
3D structure
PDB6nzu Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
ChainE
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP E A127 T128 D232 Q235 H257 K258 A72 T73 D177 Q180 H202 K203
Gene Ontology
Molecular Function
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0044571 [2Fe-2S] cluster assembly

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Molecular Function
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Biological Process
External links
PDB RCSB:6nzu, PDBe:6nzu, PDBj:6nzu
PDBsum6nzu
PubMed31101807
UniProtQ9Y697|NFS1_HUMAN Cysteine desulfurase (Gene Name=NFS1)

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