Structure of PDB 6mxx Chain E

Receptor sequence
>6mxxE (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]
NSFVGLRVVAKWSSNGYFYSGKITRDVGAGKYKLLFDDGYECDVLGKDIL
LCDPIPLDTEVTALSEDEYFSAGVVKGHRKESGELYYSIEKEGQRKWYKR
MAVILSLEQGNRLREQYGLG
3D structure
PDB6mxx An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
ChainE
Resolution2.298 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K6P E W1495 D1521 Y1523 M1584 W12 D38 Y40 M101 BindingDB: IC50=1.3e+4nM
External links
PDB RCSB:6mxx, PDBe:6mxx, PDBj:6mxx
PDBsum6mxx
PubMed37773238
UniProtQ12888|TP53B_HUMAN TP53-binding protein 1 (Gene Name=TP53BP1)

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