Structure of PDB 6mn5 Chain E

Receptor sequence
>6mn5E (length=259) Species: 562 (Escherichia coli) [Search protein sequence]
QMMQYEWRKAELIGQLLNLGVTPGGVLLVHSSFRSVRPLEDGPLGLIEAL
RAALGPGGTLVMPSWSGLDDEPFDPATSPVTPDLGVVSDTFWRLPNVKRS
AHPFAFAAAGPQAEQIISDPLPLPPHSPASPVARVHELDGQVLLLGVGHD
ANTTLALAELMAKVPYGVPRHCTILQDGKLVRVDYLENDHCCERFALADR
WLKEKSLQKEGPVGHAFARLIRSRDIVATALGQLGRDPLIFLHPPEAGCE
ECDAARQSI
3D structure
PDB6mn5 Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.
ChainE
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LLL E D67 R168 E185 C190 E249 D69 R170 E187 C192 E251
BS02 ZN E H241 C247 C250 H243 C249 C252
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6mn5, PDBe:6mn5, PDBj:6mn5
PDBsum6mn5
PubMed35338238
UniProtQ306W4

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