Structure of PDB 6mdm Chain E

Receptor sequence
>6mdmE (length=514) Species: 10029 (Cricetulus griseus) [Search protein sequence]
NPDWNFEKMGIGGLDKEFSDIFRRAFASRVFCKHVKGILLYGPPGCGKTL
LARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGA
NSGLHIIIFDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNIL
VIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMRGHQ
LLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIIVDMEKAESLQ
VTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELL
VQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMI
GFSETAKCQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQ
ALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEMLNAFSTTIHVPNIATGE
QLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEMSLQMDPEY
RVRKFLALLREEGA
3D structure
PDB6mdm Structural principles of SNARE complex recognition by the AAA+ protein NSF.
ChainE
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.6: vesicle-fusing ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E N505 G506 I507 I508 V514 G548 K549 T550 I707 K708 N281 G282 I283 I284 V290 G324 K325 T326 I483 K484
BS02 ADP E I220 P262 G263 C264 G265 K266 L268 N374 I406 H410 I11 P44 G45 C46 G47 K48 L50 N156 I188 H192
Gene Ontology
Molecular Function
GO:0000149 SNARE binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017075 syntaxin-1 binding
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030165 PDZ domain binding
GO:0035255 ionotropic glutamate receptor binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0140545 ATP-dependent protein disaggregase activity
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006813 potassium ion transport
GO:0006886 intracellular protein transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0035494 SNARE complex disassembly
GO:0043001 Golgi to plasma membrane protein transport
GO:0045732 positive regulation of protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030496 midbody

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mdm, PDBe:6mdm, PDBj:6mdm
PDBsum6mdm
PubMed30198481
UniProtP18708|NSF_CRIGR Vesicle-fusing ATPase (Gene Name=NSF)

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