Structure of PDB 6m4n Chain E

Receptor sequence
>6m4nE (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
YEAPAYHLILEGILILWIIRLLFSKTYKTVKEKEELIEEWQPEPLVPPVP
KDHPALNYNIVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALAS
LKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASA
IPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQ
EIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLE
ESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFV
IDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIH
KALQGISGLKVVGESLSPAFHLQLEESTGSREQDVRLLQEIVDQCMNRSI
ALTQARYLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVL
3D structure
PDB6m4n Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex.
ChainE
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.50: serine C-palmitoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP E S338 A339 S314 A315
Gene Ontology
Molecular Function
GO:0004758 serine C-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006686 sphingomyelin biosynthetic process
GO:0009058 biosynthetic process
GO:0030148 sphingolipid biosynthetic process
GO:0046511 sphinganine biosynthetic process
GO:0046512 sphingosine biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:1904504 positive regulation of lipophagy
GO:1904649 regulation of fat cell apoptotic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0017059 serine palmitoyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m4n, PDBe:6m4n, PDBj:6m4n
PDBsum6m4n
PubMed33558762
UniProtO15269|SPTC1_HUMAN Serine palmitoyltransferase 1 (Gene Name=SPTLC1)

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