Structure of PDB 6lxt Chain E

Receptor sequence
>6lxtE (length=114) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
VLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVK
QLSSNFGAISSVLNDILSRLDKVEDVDLGDISGINASVVNIQKEIDRLNE
VAKNLNESLIDLQE
3D structure
PDB6lxt Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.
ChainE
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E D1163 D1165 D75 D77
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lxt, PDBe:6lxt, PDBj:6lxt
PDBsum6lxt
PubMed32231345
UniProtP0DTC2|SPIKE_SARS2 Spike glycoprotein (Gene Name=S)

[Back to BioLiP]