Structure of PDB 6lwr Chain E

Receptor sequence
>6lwrE (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
PEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
NPDLLELCHSVPKEVVQLGGEEDFAAFRAWLRCYGMPGMSSLQDRHGRTI
WFQGDPGPLA
3D structure
PDB6lwr DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
ChainE
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E R118 Y263 R277 R117 Y234 R248
BS02 dna E E3 K54 G80 M81 F120 N176 R277 E2 K53 G79 M80 F119 N175 R248
BS03 dna E H96 I117 R118 R119 F120 H95 I116 R117 R118 F119
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6lwr, PDBe:6lwr, PDBj:6lwr
PDBsum6lwr
PubMed34226550
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

[Back to BioLiP]