Structure of PDB 6kc6 Chain E

Receptor sequence
>6kc6E (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNC
RVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGGGCRVI
EQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYE
VEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRR
3D structure
PDB6kc6 Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
ChainE
Resolution2.123 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E C871 C874 C890 C893 C5 C8 C24 C27
BS02 ZN E C898 C901 H926 C930 C32 C35 H60 C64
BS03 ZN E C911 C916 H923 H925 C45 C50 H57 H59
BS04 ZN E C969 C986 C998 H1001 C97 C114 C126 H129
BS05 D60 E G884 C885 M886 H887 F905 R935 G18 C19 M20 H21 F39 R69
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6kc6, PDBe:6kc6, PDBj:6kc6
PDBsum6kc6
PubMed32246052
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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