Structure of PDB 6jxk Chain E

Receptor sequence
>6jxkE (length=987) Species: 9823 (Sus scrofa) [Search protein sequence]
GMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTP
EYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALI
AVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVV
GDLVEMKGGDRVPADIRILQAQGCKVDNSSLTGESEPQTRSPECTHESPL
ETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGVENEKTPIAIE
IEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLL
ATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMT
VSHLWFDNHIHSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQ
DAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKVCEIPFNSTNK
FQLSIHTLEDPRDPRHVLVMKGAPERVLERCSSILIKGQELPLDEQWREA
FQTAYLSLGGLGERVLGFCQLYLSEKDYPPGYAFDVEAMNFPTSGLCFAG
LVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEG
SETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPE
MVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIA
GSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPEL
TPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPR
NPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLR
PQWENHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIR
KTRRLSAFQQGFFRNRILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQ
WWLVPMPFSLLIFVYDEIRKLGVRCCPGSWWDQELYY
3D structure
PDB6jxk A single K + -binding site in the crystal structure of the gastric proton pump.
ChainE
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.19: H(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR E E856 A860 E810 A814
BS02 MF4 E T228 D385 K386 T387 T626 G627 K707 N729 T182 D339 K340 T341 T580 G581 K661 N683
BS03 MG E D385 T387 D726 D339 T341 D680
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0008900 P-type potassium:proton transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006813 potassium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0071805 potassium ion transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005889 potassium:proton exchanging ATPase complex
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jxk, PDBe:6jxk, PDBj:6jxk
PDBsum6jxk
PubMed31436534
UniProtP19156|ATP4A_PIG Potassium-transporting ATPase alpha chain 1 (Gene Name=ATP4A)

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