Structure of PDB 6jlz Chain E

Receptor sequence
>6jlzE (length=409) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
LQSIPIEFQAVVFAGFGNSLYPLTGSDALPKALLPIGNKPMLHYPLYWLE
AAGFTSAILICMEEAEAHINAWLRSGYEGHMRIHVEAPTILDDSKSSADA
LRAVSHLIKNDFVCLSCDSIVGLPPYTVLDKFRLDNPSALAVYSPVLKYE
HITSQSKEIDAKQLIGIEEKTSRLLYAKSSADVGSDFTFRMSLLWKHPRV
TLNTNLSDAHIFVFKHWVIDLIREKESISSIRGDLIPYLVKCQYQKSFTV
RENIQRFLSSPSSQEIKINALIAKDGIICSRANNLPNYFELNKCIAKLTP
EQRLVDVTVSERALVGADCMVNEGTTIKDNSNIKKSIIGKNCVIGKGVVV
SNSILMDNIVVEDGVRLESCIVASGAQIGAKSKLRECEIGVDHRVEAGRI
ARGERLVDM
3D structure
PDB6jlz Structural basis for eIF2B inhibition in integrated stress response.
ChainE
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 E A337 K376 A296 K335
BS02 PO4 E N49 R263 N18 R232
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009058 biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0032045 guanyl-nucleotide exchange factor complex

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Cellular Component
External links
PDB RCSB:6jlz, PDBe:6jlz, PDBj:6jlz
PDBsum6jlz
PubMed31048492
UniProtP56288|EI2BG_SCHPO Translation initiation factor eIF2B subunit gamma (Gene Name=tif223)

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