Structure of PDB 6jhn Chain E

Receptor sequence

>6jhnE (length=3476) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD
LSICTFVLEQSLSVRALQEMLANTFMMKTAQGGGHRTLLYGHAILLRHSY
SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKV
RVGDDLILVSVSSERYLHLSYLHVDAAFQQTLWSVAPISSGSEAAQGYLI
GGDVLRLLHGECLTVPSGEHEQRRTVHYEGGAVSVHARSLWRLETLRVAW
SGSHIRWGQPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSS
KEKRKEVDGMGTSEIKYGDSVCFIQHIGTGLWLTYQSSIQRKAIMHHEGH
MDDGLNLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLP
IESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLV
LECIDRLHVYSSVAGREAGESWKSILNSLYELLAALIRGNRKNCAQFSGS
LDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKH
GRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSS
MRPNIFLGKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEE
WGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLS
APSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGEFKFLPP
PGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSAFTPIPVDTS
QIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVE
FSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAYQLTSGYKPAPMD
LSFIKLTPSQEAMVDKLAENAHNVWARDRIRQRRNPRLVPYALLDDRTKK
SNKDSLREAVRTLLGYGYNLEARFRIFRAEKTYAVKAGRWYFEFEAVTAG
DMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDV
VGCMVDMTEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQ
VGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV
PSSHEHIEVTRIDVTQKSFGSQNSSTDIMFYRLSMPIECTYYYSVRIFPN
VWVGWITSDFHQYDTAFDLVTVTLGDEKGKVHESIKRSNYMVCANGLEIG
CVVGLLTFTANGKDLSTYYQVEPSTKLFPAVFAQATSPNVFQFEAGLFKS
EHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLE
PLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVA
HALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNN
EFIVPMTEETKSITLFPDGLPGIGLSTSLRPRMQFSSPSFVSINNECYQY
SPEFPLDILKAKTIQMLTEAVQEGSLHARDPVGGTTEFLFVPLIKLFYTL
LIMGIFHNEDLKHILQLIEPSGLLQMKLPEPVKLQMCLLLQYLCDCQVRH
RIEAIVAFSDDFVAKLQDNQRFRYNEVRDQLLDFHEDLMTHCGIELDSDL
TIRGRLLSLVEKVTYLTLQQLISETMVRWAQESVIEDPELVRAMFVLLHR
QYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEK
LMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGFPKMVANCCR
FLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVM
DNNELALALREPDLEKVVRYLAGCGPVEGERYLDFLRFAVFCNGESVEEN
ANVVVRLLIRRPEGLLAAMEEAIKIGNAIMTFYAALIDLLGRCAEAIRIR
SILRSGDLVGVISIAFCPDHKAAMVLFLDRVYVQDFLLHLLGFLPDLRAA
ASLTDMALALNRYLCTAVLPLLLFAGTEHHASLIDSLLHTVKGCSLTKAQ
RDSIEVCLLSRPSMMQHLLRRLVFDVPLLNKMPLKLLTNHYERCWKYYCL
PGGASEEELHLSRKLFWGIFDALYEQELFKLALPCLSAVAGALPPNFNPQ
PVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQ
PLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDHGYSPRAI
DMSNVTLSRDLHAMAEMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDT
LTAKEKAKDREKAQDILKFLQINGYAVSRGYFLSAASRPLCSGGHASNKE
KEMVFCKLGVLVRHRISLFGNDATLHILGQTLDARTVMKTGLESVKFLDN
AAEDLEKTMENLKQGQFTTTVALLPMLSSLFEHIGQHQFLEDVQVSCYRI
LTSLYALGTSVERQRSALGECLAAFAGAAFLETHLDKHNIYSYNLPRHRA
VNLFLQGYEKSWIETEEHYFEDKLIEDLAKPRVDPLHQLILLFSRTALTE
KCKLEEDFLYMAYADIMAKSCSFEEKEMEKQKLLYQQARLHDRGAAEMVL
QTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLEYLKEKKDVGFFQ
SLAGLMQSCSVLDLNAFERQNKAEGKVLQDDEFTCDLFRFLQLLCEGHNS
DFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQG
QRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFA
HMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDM
LVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAM
ESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLL
TNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEI
SESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQL
AAQIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVVHYVLEES
SGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDG
LYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRD
RISELLGSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNF
FFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN
FFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGD
EYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETK
CFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQE
SYVWKMYQERCWEFFPAGDCFRKQYE

3D structure

• PDB: 6jhn Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
• Chain: E
• Resolution: 4.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	E	C4889 I4891 C4892 H4914	C3401 I3403 C3404 H3426
BS02	CA	E	E3923 Q3926 T4932	E2770 Q2773 T3444
BS03	CFF	E	W4646 I4927 Y4945	W3181 I3439 Y3457

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 22 22:34:18 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6jhn', asym_id = 'E', title = 'Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6jhn', asym_id='E', title='Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6jhn', asym_id = 'E'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6jhn', asym_id='E')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>