Structure of PDB 6ivx Chain E

Receptor sequence
>6ivxE (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTEIEHLVQSVCKSYRETCQRLEDLLRQRSNIFSREEVTGYQRKSMWEM
WERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMC
RAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDE
IALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKL
PPAGKLASLCSQHVERLQIFQHLHPI
3D structure
PDB6ivx Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
ChainE
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E V332 K336 I350 L353 K354 S477 E481 Q484 V66 K70 I84 L87 K88 S211 E215 Q218
BS02 AYO E C320 H323 A327 M365 A368 V376 F377 I397 I400 F401 S404 C54 H57 A61 M99 A102 V110 F111 I131 I134 F135 S138
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ivx, PDBe:6ivx, PDBj:6ivx
PDBsum6ivx
PubMed30776227
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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