Structure of PDB 6iso Chain E

Receptor sequence
>6isoE (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDSNLQQYDLPYPEAIF
ELPFFFHNKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNID
GLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCP
VCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLT
EAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTE
EMRDLVQRETGKL
3D structure
PDB6iso Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.
ChainE
Resolution2.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 N229 D231 H248
Catalytic site (residue number reindexed from 1) P34 D35 N98 D100 H117
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E H248 V292 F293 F294 G295 E323 V324 E325 H117 V161 F162 F163 G164 E192 V193 E194
BS02 ZN E C256 C259 C280 C283 C125 C128 C149 C152
BS03 CRD E F180 I230 H248 F50 I99 H117
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6iso, PDBe:6iso, PDBj:6iso
PDBsum6iso
PubMed25369635
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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