Structure of PDB 6int Chain E

Receptor sequence

>6intE (length=412) Species: 1079050 (Paenibacillus sp. R4)

FDHVGTVKFEGKSSTNPLAFKFYNPDEIILGKTMREHLRFGVAYLSGMEL
AKARVEACFELLNILDVDYFCFHDRDIAPEGDTLQETNRNLDEIVALIKQ
HMHSSGKKLLWNTANMFTNPRFVHGAATTSNADVFAYAAAQVKKALDHGK
ELGAENYVFWGGREGYESLLNTDLGLELDNLARFLQLAVDYAKEIGFDAQ
FLIEPKPKEPSKHQYDFDAATTLQFLQKYDLAKHFKLNLEANHATLAGHT
FEHELRVARINGALGSIDANQGDLLLGWDTDEFPTDLYASTLAMYEILQN
EGGIGRGGVNFDAKVRRTSFEPIDVVYAHINGMDAFARGLQVAAKLIEDR
AFDNVIEERYASFTKGIGADIVSGKANFHTLEAYALQNNPITNKSGRVEL
LRSILNQYIINV

3D structure

• PDB: 6int Crystal Structure and Functional Characterization of a Xylose Isomerase (PbXI) from the Psychrophilic Soil Microorganism, Paenibacillus sp.
• Chain: E
• Resolution: 1.942 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H99 D102 W137 E230 K232 E266 H269 D294 D305 D307 D338
• Catalytic site (residue number reindexed from 1): H73 D76 W111 E204 K206 E240 H243 D268 D279 D281 D312
• Enzyme Commision number: 5.3.1.5: xylose isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	E	E230 E266 D294 D338	E204 E240 D268 D312
BS02	CA	E	E266 H269 D305 D307	E240 H243 D279 D281
BS03	CA	E	G191 E203	G165 E177

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0009045 xylose isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0042732 D-xylose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6int, PDBe:6int, PDBj:6int
• PDBsum: 6int
• PubMed: 30602271
• UniProt: A0A4V8H014