Structure of PDB 6hxl Chain E

Receptor sequence
>6hxlE (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
PASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYS
CQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFG
GALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMR
VQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDM
LRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRH
PWDDISYVLPE
3D structure
PDB6hxl Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
ChainE
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA E R934 A938 L969 I970 M971 G972 I973 G974 R976 L1021 N1024 D1026 R98 A102 L133 I134 M135 G136 I137 G138 R140 L185 N188 D190
BS02 FLC E H900 V904 G936 H975 R986 D1026 R1065 H64 V68 G100 H139 R150 D190 R229
Gene Ontology
Molecular Function
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:6hxl, PDBe:6hxl, PDBj:6hxl
PDBsum6hxl
PubMed30944476
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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