Structure of PDB 6he5 Chain E

Receptor sequence
>6he5E (length=242) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence]
QMGYDRAITVFSPDGRLFQVEYAREAVKRGATAIGIKCKEGVILIADKRV
GSKLLEADTIEKIYKIDEHICAATSGLVADARVLIDRARIEAQINRLTYD
EPITVKELAKKICDFKQQYTQYGGVRPFGVSLLIAGVDEVPKLYETDPSG
ALLEYKATAIGMGRNAVTEFFEKEYRDDLSFDDAMVLGLVAMGLSIESEL
VPENIEVGYVKVDDRTFKEVSPEELKPYVERANERIRELLKK
3D structure
PDB6he5 Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle.
ChainE
Resolution4.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E R33 G34 A35 L81 V82 R29 G30 A31 L77 V78
BS02 peptide E R20 E25 R28 D151 R16 E21 R24 D147
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010498 proteasomal protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

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Cellular Component
External links
PDB RCSB:6he5, PDBe:6he5, PDBj:6he5
PDBsum6he5
PubMed30559193
UniProtO29760|PSA_ARCFU Proteasome subunit alpha (Gene Name=psmA)

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