Structure of PDB 6hay Chain E

Receptor sequence
>6hayE (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
SPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKELPEYYELIR
KPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIV
LQSVFKSARQKIAKE
3D structure
PDB6hay BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
ChainE
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FX8 E V1408 F1409 L1412 L1418 Y1421 V1429 A1460 F1463 N1464 I1470 V32 F33 L36 L42 Y45 V53 A84 F87 N88 I94
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0016586 RSC-type complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6hay, PDBe:6hay, PDBj:6hay
PDBsum6hay
PubMed31178587
UniProtP51531|SMCA2_HUMAN Probable global transcription activator SNF2L2 (Gene Name=SMARCA2)

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