Structure of PDB 6h1b Chain E

Receptor sequence
>6h1bE (length=487) Species: 531310 (Marinactinospora thermotolerans) [Search protein sequence]
MGYARRVMDGIGEVAVTGAGGSVTGARLRHQVRLLAHALTEAGIPPGRGV
ACLHANTWRAIALRLAVQAIGCHYVGLRPTAAVTEQARAIAAADSAALVF
EPSVEARAADLLERVSVPVVLSLGPTSRGRDIPEGTPLRYREHPEGIAVV
AFTTTGTPKGVAHSSTAMSACVDAAVSMYGRGPWRFLIPIPLSDLGGELA
QCTLATGGTVVLLEEFQPDAVLEAIERERATHVFLAPNWLYQLAEHPALP
RSDLSSLRRVVYGGAPAVPSRVAAARERMGAVLMQNYGTQEAAFIAALTP
DDHARRELLTAVGRPLPHVEVEIRDDSGGTLPRGAVGEVWVRSPMTMSGY
WRDPERTAQVLSGGWLRTGDVGTFDEDGHLHLTDRLQDIIIVEAYNVYSR
RVEHVLTEHPDVRAAAVVGVPDPDSGEAVCAAVVVADADPDPEHLRALVR
DHLGDLHVPRRVEFVRSIPVTPAGAPDKVKVRTWFTD
3D structure
PDB6h1b The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides.
ChainE
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T158 D201 Q297 E298 I398 N403 A483
Catalytic site (residue number reindexed from 1) T153 D194 Q290 E291 I391 N396 A475
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP E G271 A272 P273 Y294 D377 N403 G264 A265 P266 Y287 D370 N396
BS02 EQ2 E L202 Y294 G295 T296 A300 F301 L195 Y287 G288 T289 A293 F294
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:6h1b, PDBe:6h1b, PDBj:6h1b
PDBsum6h1b
PubMed30035356
UniProtR4R1U5

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