Structure of PDB 6gqt Chain E

Receptor sequence
>6gqtE (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
FQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVID
GETCLLDILDTAGMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRV
KDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVD
DAFYTLVREIRKHK
3D structure
PDB6gqt Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
ChainE
Resolution1.69 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP E G13 G15 K16 S17 A18 V29 D30 P34 T35 G60 N116 K117 D119 S145 G16 G18 K19 S20 A21 V32 D33 P37 T38 G63 N113 K114 D116 S142
BS02 MG E S17 T35 S20 T38
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6gqt, PDBe:6gqt, PDBj:6gqt
PDBsum6gqt
PubMed30683716
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

[Back to BioLiP]