Structure of PDB 6gog Chain E

Receptor sequence
>6gogE (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVI
DGETCLLDILDTAGHEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYR
EQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAK
TRQGVDDAFYTLVREIRKHKE
3D structure
PDB6gog Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
ChainE
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP E G13 G15 K16 S17 A18 V29 D30 Y32 P34 T35 G60 N116 K117 D119 L120 S145 A146 G17 G19 K20 S21 A22 V33 D34 Y36 P38 T39 G64 N119 K120 D122 L123 S148 A149
BS02 MG E S17 T35 S21 T39
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gog, PDBe:6gog, PDBj:6gog
PDBsum6gog
PubMed30683716
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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