Structure of PDB 6gh4 Chain E

Receptor sequence

>6gh4E (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAP
WMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHG
CELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDA
SEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEAT
LRCWALGFYPAEITLTWQQDGEGHTQTELVETRPAGDGTFQKWAAVVVPS
GEEQRYTCHVQHEGLPEPVTLRW

3D structure

PDB

6gh4 Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

Chain

Resolution

2.16 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	Y7 R62 E63 S66 T70 I73 N77 Y84 W97 H99 F116 S143 K146 Y159 W167 Y171	Y7 R62 E63 S66 T70 I73 N77 Y84 W97 H99 F116 S143 K146 Y159 W167 Y171
BS02	ZN	E	H181 E183	H181 E183

External links

PDB	RCSB:6gh4, PDBe:6gh4, PDBj:6gh4
PDBsum	6gh4
PubMed	30087334
UniProt	P13747\|HLAE_HUMAN HLA class I histocompatibility antigen, alpha chain E (Gene Name=HLA-E)

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