Structure of PDB 6g31 Chain E

Receptor sequence
>6g31E (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
QETVQRILLEPYKYLLQLAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDD
IEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHQDAVKLF
TRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQL
FSDYKNTLGLFFQIRYDYANLHSFCEDLTEGKFSFPTIHAIWSRPTQVQN
ILRQRTENIDIKKYCVHYGSFEYTRNTLKELEAKPELVALVKHLSKMFK
3D structure
PDB6g31 Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
2.5.1.29: geranylgeranyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOL E D64 D68 R73 D49 D53 R58 BindingDB: IC50=100000nM,Ki=2700nM
BS02 MG E D64 D68 D49 D53
BS03 MG E D64 D68 D49 D53
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006720 isoprenoid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6g31, PDBe:6g31, PDBj:6g31
PDBsum6g31
PubMed30275041
UniProtO95749|GGPPS_HUMAN Geranylgeranyl pyrophosphate synthase (Gene Name=GGPS1)

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