Structure of PDB 6fml Chain E

Receptor sequence
>6fmlE (length=441) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence]
GLNLIAAHSHIRGLGVDADTLEPRPSSQGLVGQEKARKAAAVVLEMIKQG
KIAGRAVLIAGPPSTGKTAIAMGMAQSLGQDVPFTTLAASEIFSLEMSKT
EALTQAFRKSIGVRIKEESEIMEGEVVEIQIDRSTGGAKQGKLTIKTTDM
EAIYDMGSKMIDAMTKERVMAGDIISIDKSSGKITKLGRSYARSRDYDAM
GVDTKFLQCPEGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEI
RSEIRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSYINRALES
DLAPIVIMASNRGVSRIRGTDYKSPHGLPLDFLDRVVIINTHPYTPDELR
QILSIRAQEEEVDLTPDALALLTKIGQEAGLRYASNLITTSQLIAAKRRA
KQVGVEDVQRSFKLFYDPARSVRFVQESEKRLIGNDGVVDF
3D structure
PDB6fml Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.
ChainE
Resolution4.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E R313 R352 R296 R335
BS02 ADP E A23 H24 H26 G45 L46 V47 S80 G82 K83 T84 Y361 R399 A7 H8 H10 G29 L30 V31 S64 G66 K67 T68 Y344 R382
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6fml, PDBe:6fml, PDBj:6fml
PDBsum6fml
PubMed29643509
UniProtG0RYC2

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