Structure of PDB 6ebk Chain E

Receptor sequence
>6ebkE (length=325) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDT
AEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHI
IEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWG
TSRWSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKI
GVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQ
AKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGA
IQVLPKLSSSIVHEIDSILGNKPYS
3D structure
PDB6ebk Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs.
ChainE
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP E G55 W57 Y90 R189 W243 S244 P245 L246 C248 K254 R264 P304 L322 G323 S325 Q329 E332 G19 W21 Y54 R153 W207 S208 P209 L210 C212 K218 R228 P268 L286 G287 S289 Q293 E296
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0016491 oxidoreductase activity
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006813 potassium ion transport
GO:0045445 myoblast differentiation
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0070995 NADPH oxidation
GO:0071805 potassium ion transmembrane transport
GO:0098900 regulation of action potential
GO:1901379 regulation of potassium ion transmembrane transport
GO:2000008 regulation of protein localization to cell surface
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0034705 potassium channel complex
GO:0043005 neuron projection
GO:0043194 axon initial segment
GO:0043679 axon terminus
GO:0044224 juxtaparanode region of axon
GO:0045202 synapse
GO:0098839 postsynaptic density membrane
GO:0098978 glutamatergic synapse
GO:1990031 pinceau fiber

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ebk, PDBe:6ebk, PDBj:6ebk
PDBsum6ebk
PubMed30109985
UniProtP62483|KCAB2_RAT Voltage-gated potassium channel subunit beta-2 (Gene Name=Kcnab2)

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