Structure of PDB 6dxx Chain E

Receptor sequence
>6dxxE (length=97) Species: 9606 (Homo sapiens) [Search protein sequence]
SPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHV
LIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVF
3D structure
PDB6dxx Molecular mechanism of activation of the immunoregulatory amidase NAAA.
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.23: ceramidase.
3.5.1.60: N-(long-chain-acyl)ethanolamine deacylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TON E W75 V76 L118 S122 W47 V48 L90 S94
BS02 WTF E A63 M64 V116 Y120 F125 A35 M36 V88 Y92 F97 BindingDB: IC50=500nM
External links
PDB RCSB:6dxx, PDBe:6dxx, PDBj:6dxx
PDBsum6dxx
PubMed30301806
UniProtQ02083|NAAA_HUMAN N-acylethanolamine-hydrolyzing acid amidase (Gene Name=NAAA)

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